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KMID : 0366220060410040297
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Korean Journal of Hematology
2006 Volume.41 No. 4 p.297 ~ p.301
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A Case of Limbic Encephalitis Developed after Allogeneic Stem Cell Transplantation
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Park Nam-Sook
Chun Jae-min
Park Nam-Hwan
Yang Young-Joon
Yun Gak-Won
Sohn Eun-Hee
Yun Hwan-Jung
Jo Deog-Yeon
Song Chang-Jun
Kim Sam-Yong
Park Sang-Eun
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Abstract
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Limbic encephalitis is a rare neurological syndrome, which develops after stem cell transplantation, and is characterized by a series of neurological symptoms, including retrograde amnesia, behavioral disturbance, and progressive intellectual deterioration and high signal intensity in the hippocampus on magnetic resonance imaging (MRI). Herein is described the case of a patient with limbic encephalitis, which developed after allogeneic bone marrow transplantation, and was possibly due to HHV-6 infection. An 18-year-old man, with acute lymphoid leukemia, who underwent HLA-matched unrelated donor bone marrow transplantation, developed a fever and chill accompanied by neurological symptoms, including behavioral disturbance and retrograde amnesia, during the bone marrow recovery phase. A brain MRI revealed bright signal-intensity in both hippocampi. Examination of his cerebrospinal fluid suggested viral encephalitis. Based on these findings, a diagnosis of viral limbic encephalitis was highly suspected. Tests for casual causes of viral limbic encephalitis, including the CMV, HZV and HSV-1 and 2, in serum or CSF were all negative. The encephalitis responded well to ganciclovir therapy.
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KEYWORD
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Limbic encephalitis, Allogeneic stem cell transplantation, HHV-6
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